Emperipolesis and cell death in NOD2-related Blau Syndrome and Crohn’s disease
نویسندگان
چکیده
Background Blau Syndrome (BS), a rare autoinflammatory disease characterized by non-caseating granulomas, is caused by gain-of-function mutations in NOD2. Crohn’s disease (CD) is associated with intestinal granulomas, and SNPs in NOD2. Emperipolesis, the ‘inside round about wandering’ of lymphocytes within other cells is a typical feature of Rosai-Dorfman disease, and seen occasionally in malignancies. Cell survival and cell death are possible outcomes for both the engulfed and engulfing cells.
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